Here is one I’ve been thinking about for a bit
It might not be your fault, but people just don’t like you. It may be racism, speciesism, or just plain hatred, but you get the worst end of the stick when it comes to people.
When you make any social interaction with another creature, the GM rolls a d6. On a 6, the creature’s starting attitude is two steps worse toward you and any group you a known to be a part of.