Let’s flip the Shadowrun coin for being settled in the 6th world.
Not Welcome
Bonus: 5 karma
You hate all this magic, tech, and spirit crap. You just want a simple life where dragons belong in books! When you resist a power from a creature or person, and the power isn’t a magic spell, attack in the physical roll, or hacking attempt, you have a -2 dice pool penalty on the resistance roll.
Thoughts?
Throat Punch Games 
My thoughts would it to be a bonus to resist magic since magic is based on the belief and consent reality of the people, but a penalty to social skills towards people who aren’t the status quo, such as known hackers and mages, metatypes that aren’t human, and active supporters of metahumainity and magic and matrix. Essentially, a flat negative bonus to anybody that doesn’t fit or agree with the characters beliefs.