Been reading some course work in anatomy. How about we dissolve or make some bones!
Casting Time: 1 action
Components: V, S
Duration: 1 action
You touch a creature on a limb. If the creature fails a Constitution save, the body limb begins to either harden as extra bones begin to grow or bones begin to degrade. The creatures takes a -1 penalty to all actions, checks, and saves. At the start of the creatures turns, it must make another save. If it succeeds, the penalty is reduced by 1. If it fails, the penalty increases by 1. If the penalty would ever be equal to the creatures proficiency bonus, the bone growth or destruction is complete and the limb becomes useless.
A remove curse, regenerate, heal, restoration, dispel good and evil, or wish spell ends this effect.
At Higher Levels: If you cast this spell using a spell slot of 5th level or higher, increase the number of targets by 1 for each spell level above 4.