I’ve been thinking of some spells I’ve seen in movies where the villain curses the hero, and the hero is disfigured. Can we do something like that?

Disfigure

5th-level necromancy

Casting Time: 1 action
Range: 60 feet
Components: V, S
Duration: 30 days

You throw raw hate at a target in range. The target must make a Constitution saving throw. If the target fails, you inflect a horrible curse upon the target bending its physical form to break spirit and spine. The target has a -2 penalty to saves and checks with one ability, a -10 feet penalty to its speed, or a -1 penalty to all attacks for the duration of the spell. A target can be affected by multiple castings of this spell, but each casting must cause a different effect.

A wish spell is the only spell can can end this effect early, you may end this spell with a thought at any time, or your death ends the curse as well.

At Higher Levels: When you cast this spell using a spell slot of 7th or 8th level, the duration is 1 year. When you cast this spell using a spell slot of 9th level, the spell lasts until it is ended by a wish spell.